Man City visit Tottenham in FA Cup, Villa at Chelsea،
FA Cup holders Manchester City face a tricky trip to Tottenham Hotspur, while in-form Aston Villa face Chelsea at Stamford Bridge in the fourth round.
Third-placed City are a point above Spurs with a game in hand in the Premier League table, while Villa are flying high in second place while Chelsea languish in 10th.
Fulham host Newcastle United and Sheffield United host Brighton & Hove Albion in other Premier League fixtures, with matches scheduled for the weekend of January 27-28.
Championship leaders Liverpool, who eliminated Arsenal in the third round, were given a more favorable draw on Monday.
Jurgen Klopp's side will host the winners of the replay between Norwich City and Bristol Rovers.
Sixth Division Maidstone United, the lowest placed team in the competition, travel to Second Division Ipswich Town.
The winners of the replay between Crystal Palace and Everton will host either Luton Town or Bolton Wanderers.
Twelve-time FA Cup winners Manchester United, who beat Wigan Athletic on Monday, will play a fourth round match at either Newport County or Eastleigh while awaiting the result of that match.
League Two side Wrexham AFC, who beat Shrewsbury Town on Sunday and also reached the fourth round last season, travel to Blackburn Rovers.
FA Cup 4th round full draw
Draw:
Watford v Southampton
Blackburn Rovers v Wrexham
Bournemouth v Swansea City
West Bromwich Albion v Brentford/Wolverhampton Wanderers
West Ham United/Bristol City v Nottingham Forest/Blackpool
Leicester City v Hull City/Birmingham City
Sheffield Wednesday v Coventry City
Chelsea v Aston Villa
Ipswich Town v Maidstone United
Liverpool v Norwich City/Bristol Rovers
Tottenham Hotspur vs Manchester City
Leeds United v Plymouth Argyle
Crystal Palace/Everton v Luton Town/Bolton Wanderers
Newport Country/Eastleigh v Manchester United
Sheffield United v Brighton & Hove Albion
Fulham v Newcastle United